ד"ר משה אמיתי

     1999-2002:  B.Sc Computer Science and Biology Bar-Ilan University, Ramat Gan, Israel.

2003-2005: M.Sc Structural Bioinformatics, Chemistry department, Bar-Ilan University, Ramat Gan, Israel. Subject: "Computational drug design for the P2Y₂ receptor".

  Supervision: Prof. Fischer Bilha.  

2006-2010: PhD Structural Bioinformatics, The institute for drug research, The Hebrew University, Jerusalem, Israel. Subject: "Reaction mechanisms in Butyrylcholinesterase enzyme - a Computational Study". Supervision: Prof. Shurki Avital.

2011-2014: Lecturer at Azrieli College of Engineering, Jerusalem.

 2012 – Current: Lecturer at Lev Academic Center (JCT), Jerusalem. 

    2010-2011 Proterec Ltd. - team leader, development of novel enzymes for the chemical industry.

2004 Shechter Award for excellent M.Sc Student, Bar-Ilan University.

Past:

• Phylogenetic analysis of phosphate binding protein sequences.
• Development of an optimization algorithm for peptides structure prediction.
• Development of database of protein complexes for the use of structural bioinformaticians.

Current:

• Applications of machine learning methods on genome and next generation sequencing (DNA seq and RNA-Seq) in cancer diagnostics.

1. Amitay M. and Shurki A. The Structure of G117H Mutant of Butyrylcholinesterase: Nerve Agents Scavenger, Proteins, Structure, Function and Bioinformatics, 2009, 77, 370-377. Q1, impact factor 2.274, Cited by 20.
2. Amitay M. and Shurki A. Hydrolysis of Nerve Agents by Mutant Butyrylcholinesterase – A Story of Two Histidines, Proteins, Structure, Function and Bioinformatics, 2011, 79, 352-364. Q1, impact factor 2.274, Cited by 13.

• Vanessa R. Pegos, Louis Hey, Jacob LaMirande, Rachel Pfeffer, Rosalie Lipsh, Moshe Amitay, Daniel Gonzalez and Mikael Elias Purification, characterization, crystallization and S-SAD phasing of the Phosphate-Binding Protein from Polaromonas, Acta Crystallographica F. 2017, 73, 342-346. Q3, impact factor 0.99, Cited by 1.

4. Moshe Amitay* and Moshe Goldstein. Evaluating the Peptide Structure Prediction Capabilities of a Purely Ab-Initio Method, Protein Engineering, Design and Selection (PEDS). 2017, 30, 723–727. Q1, impact factor 2.043, Cited by 6.

  *Corresponding author. Cover article.

5. Adamker, T. Holzer, I. Karakis, M. Amitay, E. Anis, S. R. Singer and Z. Barnett-Itzhaki Prediction of Shigellosis outcomes in Israel using machine learning classifiers, Epidemiology and Hygiene, 2018;146(11):1445-1451. Q2, impact factor 2.075, Cited by 3.
6. Malka Aker, Shirly Ohanona, Shira Fisher, Efrat Katsman, Shirit Dvorkin, Efrat Kopelowitz, Moshe Goldstein, Zohar Barnett-Itzhaki and Moshe Amitay. CDB—a database for protein heterodimeric complexes. Protein Engineering, Design and Selection, 2018. 31, 10, 361. Q1, impact factor 2.043
7. Ilan Levy, Isabella Karakis, Tamar Berman, Moshe Amitay, Zohar Barnett-Itzhaki, A hybrid model for evaluating exposure of the general population in Israel to air pollutants Environmental Monitoring and Assessment, 2020, 192,4. Q2, impact factor: 1.96.
8. Branislav Kordic, Marko Popovic, Miroslav Popovic, Moshe Goldstein, Moshe Amitay, David Dayan, A Protein Structure Prediction Program Architecture Based on a Software Transactional Memory. Revue roumaine des sciences techniques Série Électrotechnique et Énergétique, 2020. impact factor: 0.763. Accepted for publication.

Lecture in Conference  

1. December 2009, Israel- Germany Computational Chemistry Symposium of Lise Meitner and Fritz-Haber Minerva Centers, Jerusalem. "Hydrolysis of organophosphates by Mutant Butyrylcholinesterase – A story of two hystidines".
2. Amitay, M. Goldstein: "Evaluating the peptide structure prediction capabilities of a purely ab-initio method", a short talk presented at the 82th Conference of the Israel Chemical Society, Tel-Aviv, Israel, 2017.

Invited Lectures

1. April 2008, the Israel Institute of Biological Research, Ness-Tziona (IIBR). "The Mechanism of Nerve Agents Hydrolysis by Mutant G117H of Butyrylcholinesterase - A Computational Study".
2. June 2009, Nuclear Research Center Negev (NRCN), Dimona, "Theoretical study of the catalysis of nerve agents and other organophosphate esters".

    Poster presentation in conferences

1. Amitay M. and Shurki A. The Hydrolysis of Nerve Agents in Butyrylcholinesterase –

a Story of Two Histidines, Lisa Meitner conference for quantum chemistry, Jerusalem, 2007.

2. Amitay M. and Shurki A. The Structure of Nerve Agent Scavenger - G117H Mutant of Butyrylcholinesterase, Israel Chemical Society conference, Tel Aviv, 2007.
3. Amitay M. and Shurki A. An Activation Mechanism of Prodrugs in Butyrylcholinesterase, Israel Chemical Society conference, Jerusalem, 2008.
4. Amitay M. and Shurki A. An Activation Mechanism of a Drug by Carboxylesterases, Lisa Meitner conference for quantum chemistry, Jerusalem, 2008.
5. Amitay and Shurki A. The Activation Mechanism of a Chemotherapy Agent (CPT-11) by Carboxylesterases, Israel Chemical Society conference, Tel Aviv, 2009.
6. Amitay, M. Goldstein: "Evaluating the peptide structure prediction capabilities of a purely ab-initio method", Israel Chemical Society conference, Tel Aviv, 2017.

1. Introduction to Bioinformatics (course materials development).
2. Python for bioinformatics (course materials development).
3. Structural Bioinformatics (course materials development)..
4. Molecular Modeling Workshop (course materials development).
5. Classical Genetics (course materials development).
6. Bioinformatics final Project.
7. General Chemistry for Engineers.

Student Supervision

1. Rosalie Lipsh and Rachel Fefer, JCT's Program for Excellence 2014 – Phylogenetic analysis of phosphate binding protein sequences.
2. Hodaya Chainere and Chava Kir-on. JCT's Program for Excellence 2016 - Evaluation of the structure prediction accuracy of peptides using DEEPSAM algorithm.
3. Malki Aker and Shierly Ochnona. JCT's Program for Excellence 2018 - CDB - a Database for Protein heterodimeric complexes.